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TRAVAUX DE RECHERCHE EN COURS

COORDONNÉ PAR LE STIS

Collaborative ENTIS  study on fingolimod exposure during pregnancy.

 

Prediction of infant drug exposure to antidepressants through breastfeeding using population pharmacokinetic modeling and simulation.

 

Lactobank: use of population pharmacokinetic modeling to investigate the magnitude and determinants of drug excretion into breastmilk.

 

Use of population pharmacokinetic modeling to investigate the pharmacokinetic of drugs in pregnancy.

 

AVEC LA PARTICIPATION DU STIS

 

ENTIS multicenter case series on RAAS-inhibitors during the second and/or third trimester of pregnancy.

 

Collaborative ENTIS work on adherence to pharmacotherapy during pregnancy - opportunities to improve maternal-fetal health.

 

Multicohort analysis on efavirenz safety during pregnancy  (MoChiV and SHCS, in collaboration with PENTA and ECS).

 

Individual patient data meta-analysis on maternal depression, antidepressant use, and adverse pregnancy outcomes.

 

 

PUBLICATIONS

2018

Winterfeld U, Weber-Schöndorfer C, Schaefer C, von Elm E, Buclin T. Ethical approval for multicenter cohort studies on drug exposure during pregnancy: A survey among members of the European Network of Teratology Information Services (ENTIS). Reprod Toxicol. 2018 Jun 18. [Epub ahead of print].

 

Crettenand M, Rossetti AO, Buclin T, Winterfeld U. [Use of antiepileptic drugs during breastfeeding : What do we tell the mother?] Nervenarzt. 2018 Feb 27. [Epub ahead of print].

 

Lupattelli A, Twigg MJ, Zagorodnikova K, Moretti ME, Drozd M, Panchaud A, Rieutord A, Juraski RG, Odalovic M, Kennedy D, Rudolf G, Juch H, Nordeng H. Self-reported perinatal depressive symptoms and postnatal symptom severity after treatment with antidepressants in pregnancy: a cross-sectional study across 12 European countries using the Edinburgh Postnatal Depression Scale. Clin Epidemiol. 2018 Jun 6;10:655-669.

 

Collin-Lévesque L, El-Ghaddaf Y, Genest M, Jutras M, Leclair G, Weisskopf E, Panchaud A, Ferreira E. Infant Exposure to Methylphenidate and Duloxetine During Lactation. Breastfeed Med. 2018 Apr;13(3):221-225.

 

Panchaud A, Rousson V, Vial T, Bernard N, Baud D, Amar E, De Santis M, Pistelli A, Dautriche A, Beau-Salinas F, Cassina M, Dunstan H, Passier A, Kaplan YC, Duman MK, Maňáková E, Eleftheriou G, Klinger G, Winterfeld U, Rothuizen LE, Buclin T, Csajka C, Hernandez-Diaz S. Pregnancy outcomes in women on metformin for diabetes or other indications among those seeking teratology information services. Br J Clin Pharmacol. 2018 Mar;84(3):568-578.

 

2017

Panchaud A, Hernandez-Diaz S, Freeman MP, Viguera AC, MacDonald SC, Sosinsky AZ, Cohen LS. Use of atypical antipsychotics in pregnancy and maternal gestational diabetes. J Psychiatr Res. 2017 Jul 29;95:84-90.

 

Weisskopf E, Panchaud A, Nguyen KA, Grosjean D, Hascoët JM, Csajka C, Eap CB, Ansermot N; collaborators of the SSRI-Breast Milk study. Simultaneous determination of selective serotonin reuptake inhibitors and their main metabolites in human breast milk by liquid chromatography-electrospray mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jul 1;1057:101-109.

 

Friedrich S, Beyersmann J, Allignol A, Winterfeld U, Schumacher M. Nonparametric estimation of pregnancy outcome probabilities. Annals of Applied Statistics. 2017.11 (2):840–867.

 

Marzolini C, Decosterd L, Winterfeld U, Tissot F, Francini K, Buclin T, Livio F. Free and total plasma concentrations of elvitegravir/cobicistat during pregnancy and postpartum: a case report. Br J Clin Pharmacol. 2017 May 16. doi: 10.1111/bcp.13310. [Epub ahead of print] .

 

Patorno E, Bateman BT, Huybrechts KF, MacDonald SC, Cohen JM, Desai RJ, Panchaud A, Mogun H, Pennell PB, Hernandez-Diaz S. Pregabalin use early in pregnancy and the risk of major congenital malformations. Neurology. 2017 May 23;88(21):2020-2025.

 

Vouga M, Musso D, Schaub B, Panchaud A, Baud D. Zika virus: are we going too far? Lancet. 2017 Jan 14;389(10065):151.

 

2016

Weisskopf E, Panchaud A, Nguyen KA, Grosjean D, Hascoët JM, Csajka C, Eap CB, Ansermot N; collaborators of the SSRI-Breast Milk study. Stereoselective determination of citalopram and desmethylcitalopram in human plasma and breast milk by liquid chromatography tandem mass spectrometry. J Pharm Biomed Anal. 2016 Nov 30;131:233-245.

 

Baud D, Gérardin P, Merriam A, Alves MP, Musso D, Genton B, Panchaud A. Harness shared data in international Zika registry. BMJ. 2016 Oct 5;355:i5319.

 

Panchaud A, Vouga M, Musso D, Baud D. An international registry for women exposed to Zika virus during pregnancy: time for answers. Lancet Infect Dis. 2016 Sep;16(9):995-6.

 

Panchaud A, Stojanov M, Ammerdorffer A, Vouga M, Baud D. Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes. Clin Microbiol Rev. 2016 Jul;29(3):659-94.

 

Vouga M, Musso D, Panchaud A, Baud D. Clinical management of pregnant women exposed to Zika virus. Lancet Infect Dis. 2016 Jul;16(7):773.

 

Winterfeld U, Merlob P, Baud D, Rousson V, Panchaud A, Rothuizen LE, Bernard N, Vial T, Yates LM, Pistelli A, Ellfolk M, Eleftheriou G, de Vries LC, Jonville-Bera A-P, Kadioglu M, Biollaz J, Buclin T. Pregnancy outcome following maternal exposure to pregabalin may call for concern. Neurology.2016 Jun 14;86(24):2251-7.

 

Weisskopf E, Fumeaux CJ, Bickle Graz M, Harari MM, Epiney M, Tolsa CB, Rouiller S, Tolsa JF, Eap CB, Vial Y, Csajka C, Panchaud A. SSRI antidepressant use during pregnancy and the assessment of the risk-benefit ratio. Rev Med Suisse. 2016 Mar 16;12(510):561-6.

 

Baud D, Van Mieghem T, Musso D, Truttmann AC, Panchaud A, Vouga M. Clinical management of pregnant women exposed to Zika virus. Lancet Infect Dis. 2016 Apr 4. pii: S1473-3099(16)30008-1.

 

Corbel A, Baud D, Chaouch A, Beney J, Csajka C, Panchaud A. Utility of an Algorithm to Increase the Accuracy of Medication History in an Obstetrical Setting. PLoS One. 2016 Mar 21;11(3):e0151205.

 

Dao K, Chtioui H, Rothuizen LE, Diezi L, Prod'hom S, Winterfeld U, Buclin T, Livio F. Pharmacovigilance update. Rev Med Suisse. 2016 Jan 13;12(500):75-9.

 

Panchaud A, Di Paolo ER, Koutsokera A, Winterfeld U, Weisskopf E, Baud D, Sauty A, Csajka C. Safety of Drugs during Pregnancy and Breastfeeding in Cystic Fibrosis Patients. Respiration. 2016;91(4):333-48.

 

2015

Winterfeld U, Klinger G, Panchaud A, Stephens S, Arnon J, Malm H, te Winkel B, Clementi M, Pistelli A, Manakova E, Eleftheriou G, Merlob P, Kaplan YC, Buclin T, Rothuizen LE. Pregnancy outcome following maternal exposure to mirtazapine: a multicentre prospective study. J Clin Psychopharmacol. 2015;35(3):250-9.

 

Weber-Schoendorfer C, Oppermann M, Wacker E, Bernard N, Beghin D, Cuppers-Maarschalkerweerd B, Richardson JL, Rothuizen LE, Pistelli A, Malm H, Eleftheriou G , Kennedy D, Kadioglu Duman M, Meister R, Schaefer C. Pregnancy outcome after TNF-α inhibitor therapy during the first trimester. A prospective multicenter cohort study. Br J Clin Pharmacol. 2015;80(4):727-39.

 

Lupattelli A, Spigset O, Björnsdóttir I, Hämeen-Anttila K, Mårdby AC, Panchaud A, Juraski RG, Rudolf G, Odalovic M, Drozd M, Twigg MJ, Juch H, Moretti ME, Kennedy D, Rieutord A, Zagorodnikova K, Passier A, Nordeng H. Patterns and factors associated with low adherence to psychotropic medications during pregnancy--a cross-sectional, multinational web-based study.

Depress Anxiety. 2015;32(6):426-36.

 

Weisskopf E, Fischer CJ, Bickle Graz M, Morisod Harari M, Tolsa JF, Claris O, Vial Y, Eap CB, Csajka C, Panchaud A. Risk-benefit balance assessment of SSRI antidepressant use during pregnancy and lactation based on best available evidence.

Expert Opin Drug Saf. 2015;14(3):413-27.

 

Winterfeld U, Baud D, Panchaud A, Rothuizen L, Livio F, Stoller R, Buclin T. Exposition in utero au paracétamol et troubles du développement: des doutes insuffisants pour changer nos pratiques! pharmaJournal 23 | 11.2015: 11-12.

 

Winterfeld U, Baud D, Panchaud A, Rothuizen L, Livio F, Stoller R, Buclin T. Exposition in utero au paracétamol et troubles du développement: des doutes insuffisants pour changer nos pratiques! Bulletin Des Médecins Suisses – Schweizerische Ärztezeitung – Bollettino Dei Medici Svizzeri 2015;96(41):1494–1495.

 

2014

Winterfeld U, Rothuizen LE, Gotta V, Panchaud A, Rossetti AO, Buclin T. Anwendung von Antiepileptika bei Frauen im gebärfähigen Alter und in der Schwangerschaft: Vergleich der Fachinformationen in Deutschland und der Schweiz.

Der Nervenarzt. 2014 85(6):738-46.

 

Panchaud A, Weisskopf E, Winterfeld U, Baud D, Eap CB, Csajka C, Widmer N. Modifications pharmacocinétiques liées à la grossesse et place du suivi thérapeutique pharmacologique? Thérapie 2014,69(3):223-34.

 

Csajka C, Jaquet A, Winterfeld U, Meyer Y, Einarson A, Panchaud A. Risk perception by healthcare professionals related to drug use during pregnancy: a Swiss survey. Swiss Medical Weekly, 2014;144:w13936.

 

Weber-Schoendorfer C, Chambers C, Wacker E, Beghin D, Bernard N; on behalf of the network of French pharmacovigilance centers, Shechtman S, Johnson D, Cuppers-Maarschalkerweerd B, Pistelli A, Clementi M, Winterfeld U, Eleftheriou G, Pupco A, Kao K, Malm H, Elefant E, Koren G, Vial T, Ornoy A, Meister R, Schaefer C. Pregnancy outcome after rheumatologic methotrexate (MTX) treatment prior to or during early pregnancy: A prospective multicenter cohort study.

Arthritis Rheumatol. 2014;66(5):1101-10.

 

Lupattelli A, Spigset O, Twigg MJ, Zagorodnikova K, Mårdby AC, Moretti ME, Drozd M, Panchaud A, Hämeen-Anttila K, Rieutord A, Gjergja Juraski R, Odalovic M, Kennedy D, Rudolf G, Juch H, Passier A, Björnsdóttir I, Nordeng H. Medication use in pregnancy: a cross-sectional, multinational web-based study. BMJ Open. 2014 17;4(2).

 

2013

Winterfeld U, Allignol A, Panchaud A, Rothuizen LE, Merlob P, Cuppers-Maarschalkerweerd B, Vial T, Stephens S, Clementi M, De Santis M, Pistelli A, Berlin M, Eleftheriou G, Maňáková E, Buclin T. Author’s response to: Statins in pregnancy: safety and perspectives of therapeutic applications. BJOG. 2013;120(11):1440.

 

Winterfeld U, Allignol A, Panchaud A, Rothuizen LE, Merlob P, Cuppers-Maarschalkerweerd B, Vial T, Stephens S, Clementi M, De Santis M, Pistelli A, Berlin M, Eleftheriou G, Maňáková E, Buclin T. Pregnancy outcome after maternal exposure to statins: a multicenter prospective study. BJOG. 2013;120(4):463-71.

 

Weisskopf E, Lepigeon K, Baud D, Csajka C, Panchaud A. Médicaments tocolytiques : utilisation en cas de menace d’accouchement prématuré. pharmaJournal 2013; 19(9):5-7.

 

Weisskopf E, Lepigeon K, Fischer C, Morisod M, Bickle M, Eap CB., Tolsa JF., Vial Y, Csajka C, Panchaud A. Une étude multicentrique : antidépresseurs, grossesse et allaitement. Forum gynécologie suisse, 2013 ; 13(2):4-6.

 

Panchaud A, Berger J, Bugnon O. Médicaments, grossesse et allaitement. BabyGuide. Le manuel officiel suisse 2013 ; 31-33.

 

Panchaud A, Berger J, Csajka C, Bugnon O. Médicaments, grossesse et allaitement: toutes les sources d'information ne sont pas fiables! pharmaJournal, 2013; 1:15-16.

 

2012

Panchaud A, Csajka C, Merlob P, Schaefer C, Berlin M, De Santis M, Vial T, Ieri A, Malm H, Eleftheriou G, Stahl B, Rousso P, Winterfeld U, Rothuizen LE, Buclin T. Pregnancy Outcome Following Exposure to Topical Retinoids: A Multicenter Prospective Study. J Clin Pharmacol. 2012;52(12):1844-51.

 

Einarson A, Smart K, Vial T, Diav-Citrin O, Yates L, Stephens S, Pistelli A, Kennedy D, Taylor T, Panchaud A, Malm H, Koren G, Einarson TR. Rates of major malformations in infants following exposure to duloxetine during pregnancy: a preliminary report.

J Clin Psychiatry. 2012;73(11):1471.

 

Klieger-Grossmann C, Weitzner B, Panchaud A, Pistelli A, Einarson TR, Koren G, Einarson A. Escitalopram use in Pregnancy: an observational cohort study. J Clin Pharmacol. 2012;52(5):766-70.

 

Winterfeld U, Meyer Y, Panchaud A, Einarson A. Management of defective and insufficient lactation in Switzerland and Canada: a survey of midwives’ current practice. Breastfeeding Medicine. 2012;7:317-8.

 

Wettach C, Thomann J, Lambrigger-Steiner C, Buclin T, Desmeules J, von Mandach U. Pharmacovigilance in pregnancy: adverse drug reactions associated with fetal disorders. J Perinat Med. 2012;2;0(0):1-7.

 

Winterfeld U, Buclin T. Beratung und Dokumentation zur Arzneimittelanwendung in Schwangerschaft und Stillzeit. Pharmazeutische Medizin. 2012 2: 116-119.

 

Panchaud A, Verdun FR, Csajka C. Un examen radiologique est-il toujours à risque pour l’enfant à naître? Journal Suisse de Pharmacie 2012 n°17.

 

 

 

 

© Swiss Teratogen Information Service  2016.

Dernière mise à jour: 3.7.2018